A noted pharmacologist, Ian Creese during the course of his research career has shed new light on the effect of antipsychotic drugs on the inner workings of the brain, specifically looking at such disorders as schizophrenia and Parkinson’s. Further paving the way for a deeper understanding of the brain, Creese as co-founder and co-director of the Center for Molecular and Behavioral Neuroscience (CMBN) has paved the way for other researchers and students to unlock the secrets of brain development and neurological disorders. Creese, working with co-director and co-founder Paula Tallal, has established CMBN since its founding in 1985 as an internationally recognized neuroscience research center focused on a wide-range of brain functions and disorders, from brain development in children, to memory formation, to Alzheimer’s, dyslexia and Parkinson’s disease. Creese also is co-director of the Integrative Neuroscience Graduate Program at the University of Medicine and Dentistry of New Jersey. As a researcher, Creese is a world-renowned expert in the field of dopamine receptors and the role antipsychotic drugs play in receptor changes. Among his major findings, his research has shown that while antipsychotic drug treatment has focused on regulating dopamine receptors, regulating serotonin and glutamate receptors also may be important to increase the efficacy of drug therapies for such disorders as schizophrenia and Parkinson’s.
Ian Creese studied psychology at the University of Cambridge, where he earned his bachelor’s, master’s and doctoral degrees in experimental psychology. He served as a postdoctoral fellow at the Johns Hopkins University Medical School in Baltimore. He joined the faculty of the University of California at San Diego, School of Medicine, in 1978, before coming to Rutgers University, Newark in 1987 to co-found the Aidekman Center for Molecular and Behavioral Neuroscience with Paula Tallal. Creese has published nearly 150 research articles, scores of invited chapters and has edited four books. His research is so widely recognized that he was listed as a "Citation Superstar" by the Science Citation Index with more 5,000 citations to his research. For his accomplishments, Creese was named a Rutgers Board of Governors Professor of Neuroscience in 2001, the university's highest academic honor.
Dopamine, Encyclopedia of the Human Brain, Academic Press, 2002.
Delivery of Antisense Oligonucleotides to the Brain to Analyze Receptor Function, Genetic Manipulation of Receptor Expression and Function, Wiley-Liss, Inc., 2000.
Regulation of Neurotransmitter Receptors by Antipsychotic Drugs, Neurotransmitter Receptors in Actions of Antipsychotic Medications, CRC Press, 2000.
Antisense Knockdown of Dopamine Receptors, Central Nervous System Diseases, Humana Press, 1999.
Electrophysiological and Behavioral Effects of Dopamine Receptor Knockdown in the Brain, Antisense Technology in the Central Nervous System, Oxford University Press, 1999.